Favipiravir (T-705)

Katalognr.S7975 Batch:S797506

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Tekniska data

Formel

C5H4FN3O2
Molekylvikt 157.1 CAS-nr. 259793-96-9
Löslighet (25°C)* In vitro DMSO 31 mg/mL (197.32 mM)
Ethanol 5 mg/mL (31.82 mM)
Water 2.5 mg/mL (15.91 mM)
In Vivo (Tillsätt lösningsmedel till produkten individuellt och i ordning.)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml betyder svårlösligt eller olösligt.
* Vänligen notera att Selleck testar lösligheten för alla förbindelser internt, och den faktiska lösligheten kan skilja sig något från publicerade värden. Detta är normalt och beror på små variationer mellan olika partier.
* Rumstempererad frakt (Stabilitetstester visar att denna produkt kan fraktas utan några kylåtgärder.)

Beredning av stamlösningar

Biologisk aktivitet

Beskrivning Favipiravir (T-705) är en potent och selektiv RNA-beroende RNA-polymeras-hämmare som används för att behandla infektioner orsakade av influenza virus.
Mål
RNA-dependent RNA polymerase
In vitro Favipiravir (T-705) shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), it shows no cytotoxicity at concentrations up to 1,000 μg/ml. In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, this compound induces lethal mutagenesis.
In Vivo Favipiravir (T-705) protects influenza virus-infected mice from death when administered at 200 mg/kg/day (p.o.). In mice experimentally infected with Ebola virus, this compound efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6 days after initiation of treatment, respectively.

Protokoll (från referens)

Cellanalys:[1]
  • Cellinjer

    MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells

  • Koncentrationer

    1000 μg/mL

  • Inkubationstid

    3 days

  • Metod

    The cytotoxicity of Favipiravir (T-705) is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compound is diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).
Djurstudie:[1]
  • Djurmodeller

    Mice infected with influenza virus A/PR/8/34

  • Doseringar

    200 mg/kg/day

  • Administrering

    p.o.

Referenser

  • https://pubmed.ncbi.nlm.nih.gov/11897578/
  • https://pubmed.ncbi.nlm.nih.gov/23325689/
  • https://pubmed.ncbi.nlm.nih.gov/26343011/

Kundvalidering av produkt

(A) BoDV-1 infection was measured by IFA. BoDV-1 P40 was detected with a primary monoclonal antibody (red), nuclei were stained with DAPI (blue), merged image (scale bars: 50 μm). Favipiravir: T-705

Data från [ , , Cell Physiol Biochem, 2018, 49(1):381-394 ]

(B) IFA of Vero-rBoDV-1-Gluc cells treated with T-705. Vero-rBoDV-1-Gluc cells were treated as indicated and the cells were stained with an anti-P antibody (shown in green) and DAPI (shown in blue). Bars, 50 μm.

Data från [ , , Antiviral Res, 2017, 143:237-245 ]

Sellecks Favipiravir (T-705) Har citerats av 29 Publikationer

Remdesivir as a potent antiviral against prototype and current epidemic Oropouche virus strains (BeAn19991 and PE-IAM4637) [ Virus Res, 2026, 363:199680] PubMed: 41422843
Differential tropisms of old and new world hantaviruses influence virulence and developing host-directed antiviral candidates [ PLoS Pathog, 2025, 21(8):e1013401] PubMed: 40857262
Dysregulated glycerophospholipid metabolism in amygdala may mediate favipiravir-induced anxiety-like behaviors in mice [ Front Pharmacol, 2025, 16:1491150] PubMed: 40103591
Favipiravir as a potent inhibitor of Newcastle disease virus: in ovo efficacy, dose-dependent toxicity, and molecular insights into RNA polymerase inhibition [ Vet World, 2025, 18(9):2785-2797] PubMed: 41113231
Identification of dihydroorotate dehydrogenase inhibitor, vidofludimus, as a potent and novel inhibitor for influenza virus [ J Med Virol, 2024, 96(1):e29372] PubMed: 38235544
High-dose modified-release formulation of a poorly soluble drug via twin-screw melt coating and granulation [ International Journal of Pharmaceutics, 2024, 125090] PubMed: 39681221
High-dose modified-release formulation of a poorly soluble drug via twin-screw melt coating and granulation [ Int J Pharm, 2024, 670:125090] PubMed: 39681221
ProcCluster® and procaine hydrochloride inhibit the growth of Aspergillus species and exert antimicrobial properties during coinfection with influenza A viruses and A. fumigatus in vitro [ Front Cell Infect Microbiol, 2024, 14:1445428] PubMed: 39473925
ヒト iPS 細胞由来心筋細胞を用いた慢性収縮毒性評価法の開発 [ Okayama University, 2023 , 10.18926/65391] PubMed: none
Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association [ Nat Commun, 2022, 13(1):2256] PubMed: 35474062

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