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Elamipretide (SS-31, MTP-131)

Kat.nr.S9803

Elamipretide (MTP-131, SS-31) är en cytochrome c peroxidase-hämmare. Elamipretide förbättrar mitokondriell dysfunktion, synaptisk och minnesnedsättning inducerad av lipopolysackarid hos möss.

Aminosyrasekvens

Elamipretide (SS-31, MTP-131) Amino-acid Sequence

CAS-nr. 736992-21-5

Sellecks Elamipretide (SS-31, MTP-131) Har citerats av 16 Publikationer

Kvalitetskontroll

Batch: Renhet: 99.37%

99.37

Kemisk information & löslighet

Lagring (från mottagningsdatumet)	3 years -20°C powder	Lagring av stamlösningar Alikvotera stamlösningarna för att undvika upprepade frys-tiningscykler.	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

Water : 100 mg/mL

Molekylviktsräknare

In Vivo
Batch:

Tillsätt lösningsmedel till produkten individuellt och i ordning.

In vivo-formuleringsräknare

Biologisk aktivitet

Beskrivning	Elamipretide (MTP-131, SS-31) är en cytochrome c peroxidase-hämmare. Elamipretide förbättrar mitokondriell dysfunktion, synaptisk och minnesnedsättning inducerad av lipopolysackarid hos möss.
Targets/IC₅₀/Ki	cytochrome c peroxidase

In vitro
In vitro	Elamipretide (SS-31, MTP-131) binds with high affinity to cardiolipin, an anionic phospholipid expressed on the inner mitochondrial membrane that is required for cristae formation. In addition, the complex of this compound with cardiolipin inhibits cytochrome c peroxidase activity, which catalyzes cardiolipin peroxidation and results in mitochondrial damage during ischemia, by protecting its heme iron.
Cellforskning	Cellinjer	feline kidney cells
	Koncentrationer	0.1-10 μM
	Inkubationstid	1 hour
	Metod	Intracellular targeting of Elamipretide (SS-31, MTP-131) is determined by incubating feline kidney cells, grown in biotin-free media for 24 hours, with biotinylated compound for 1 hour. Cells are then fixed with 4% paraformaldehyde, permeabilized with 0.1% triton, and treated with Streptavidin-AlexaFluor594 for 30 minutes at room temperature. Fluorescence staining is observed by wide-field fluorescent microscope.

In Vivo
In Vivo	Pretreatment of rats with Elamipretide (SS-31, MTP-131) protects cristae membranes during renal ischemia and prevents mitochondrial swelling. Prompt recovery of ATP on reperfusion leads to rapid repair of ATP-dependent processes, such as restoration of the actin cytoskeleton and cell polarity. Rapid recovery of ATP also inhibits apoptosis, protects tubular barrier function, and mitigates renal dysfunction.
Djurforskning	Djurmodeller	male Sprague–Dawley rats
	Doseringar	2.0 mg/kg
	Administrering	SC

Referenser
https://pubmed.ncbi.nlm.nih.gov/23813215/ https://pubmed.ncbi.nlm.nih.gov/31747905/

Referenser

https://pubmed.ncbi.nlm.nih.gov/23813215/
https://pubmed.ncbi.nlm.nih.gov/31747905/

Produktinformation

Molekylformel	C₃₂H₄₉N₉O₅
Molekylvikt	639.79
CAS-nr.	736992-21-5
Lagring (Från mottagningsdatumet)	3 years -20°C powder
Frakt	Rumstempererad frakt (Stabilitetstester visar att denna produkt kan fraktas utan några kylåtgärder.)